abstract：:Neural cell adhesion molecule (NCAM) is known as the cell surface glycoprotein, and it belongs to the immunoglobulin superfamily of adhesion molecules. Polysialic acid (PSA) is a carbohydrate attached to NCAM via either of two specific sialyltransferases: ST8SiaII and ST8SiaIV. Polysialylated neural cell adhesion mole...

journal_title：Brain research

authors： Lobanovskaya N,Zharkovsky T,Jaako K,Jürgenson M,Aonurm-Helm A,Zharkovsky A

更新日期：2015-11-02 00:00:00

abstract：:Reciprocal interactions between nitrergic and dopaminergic systems play a key role in the control of motor behavior. In the present study, we performed a comparative analysis of motor behavior (locomotor activity, catalepsy, rotational behavior) and monoamine metabolism in the striatum and substantia nigra of unilater...

journal_title：Brain research

authors： Czarnecka A,Konieczny J,Lenda T,Lorenc-Koci E

更新日期：2015-11-02 00:00:00

abstract：:Extracellular signal-regulated kinase 1/2 (ERK1/2) plays diverse roles in the central nervous system. Activation of ERK1/2 has been observed in various types of neuronal excitation, including seizure activity in vivo and in vitro. However, studies examining ERK1/2 activity and its substrate phosphorylation in parallel...

journal_title：Brain research

authors： Yamagata Y,Nairn AC

更新日期：2015-11-02 00:00:00

abstract：:In response to in vitro stimulation with lipopolysaccharide (LPS), microglia induce the production of the inflammatory cytokine interleukin-1 beta (IL-1β) together with nitric oxide (NO) and superoxide anion (O2(-)). Here we investigated the role of NO and O2(-) in the signaling mechanism by which IL-1β is induced in ...

journal_title：Brain research

authors： Sudo K,Takezawa Y,Kohsaka S,Nakajima K

更新日期：2015-11-02 00:00:00

abstract：:Gastrin-releasing peptide (GRP) mediated signals in the central nervous system (CNS) influence many functions associated with energy metabolism. The purpose of the present study was to investigate the central effect of GRP on glucose metabolism in the male rat. Intracerebroventricular (icv) administration of GRP cause...

journal_title：Brain research

authors： Jha PK,Foppen E,Challet E,Kalsbeek A

更新日期：2015-11-02 00:00:00

abstract：:We have explored the potential neuroprotective effect of local lentiviraly-mediated overexpression of nerve growth factor (NGF) on in vivo long-term potentiation (LTP) in the rat hippocampus under pathological conditions. The suspension of lentiviral particles was prepared using a genetic construct containing the huma...

journal_title：Brain research

authors： Uzakov SS,Ivanov AD,Salozhin SV,Markevich VA,Gulyaeva NV

更新日期：2015-10-22 00:00:00

abstract：:Hippocampal neurogenesis plays a very important role in learning and memory functions. In a search for best neurological drugs that protect neuronal cells and stimulate neurogenesis with no side effects, cannabinoids proved to be a strong group of substances having many beneficial properties. The aim of this study was...

journal_title：Brain research

authors： Andres-Mach M,Haratym-Maj A,Zagaja M,Rola R,Maj M,Chrościńska-Krawczyk M,Luszczki JJ

更新日期：2015-10-22 00:00:00

abstract：:Using fMRI, cerebral activations were studied in 24 classically-trained keyboard performers and 12 musically unskilled control subjects. Two groups of musicians were recruited: improvising (n=12) and score-dependent (non-improvising) musicians (n=12). While listening to both familiar and unfamiliar music, subjects eit...

journal_title：Brain research

authors： Harris R,de Jong BM

更新日期：2015-10-22 00:00:00

abstract：:Developmental delay, cognitive impairment, and refractory epilepsy are the most frequent consequences found in patients suffering from malformations of cortical development (MCD). However, therapeutic options for these psychiatric and neurological comorbidities are currently limited. The development of white matter un...

journal_title：Brain research

authors： Ma L,Yang F,Zhao R,Li L,Kang X,Xiao L,Jiang W

更新日期：2015-10-05 00:00:00

abstract：:Serotonin (5-HT) participates in pain modulation by interacting with different 5-HT receptors. The role of 5-HT5A receptor in neuropathic pain has not previously studied. The purpose of this study was to investigate: A) the role of 5-HT5A receptors in rats subjected to spinal nerve injury; B) the expression of 5-HT5A ...

journal_title：Brain research

authors： Avila-Rojas SH,Velázquez-Lagunas I,Salinas-Abarca AB,Barragán-Iglesias P,Pineda-Farias JB,Granados-Soto V

更新日期：2015-10-05 00:00:00

abstract：:The misfolding and aggregation of the Aβ peptide - a fundamental event in the pathogenesis of Alzheimer׳s disease - can be instigated in the brains of experimental animals by the intracranial infusion of brain extracts that are rich in aggregated Aβ. Recent experiments have found that the peripheral (intraperitoneal) ...

journal_title：Brain research

authors： Cintron AF,Dalal NV,Dooyema J,Betarbet R,Walker LC

更新日期：2015-10-05 00:00:00

abstract：:Results from clinical studies provide evidence that cognitive changes relatively late in life may be traced to antecedent conditions including diabetes, obesity, a sedentary lifestyle, and an atherogenic diet. As such, several traits of Type 2 diabetes (T2DM) could be considered pathogenic factors of aging, contributi...

journal_title：Brain research

authors： Maimaiti S,DeMoll C,Anderson KL,Griggs RB,Taylor BK,Porter NM,Thibault O

更新日期：2015-09-24 00:00:00

abstract：:William James noted that memories could persist from minutes to weeks. This essay attempts to explain this variation by situating the explanation in the biochemistry of dendritic spines. Two outcomes are critical to generate the synaptic basis of memory: (1) the actin cytoskeleton in the spine must be degraded to perm...

journal_title：Brain research

authors： Rudy JW

更新日期：2015-09-24 00:00:00

abstract：:Considerable research indicates that long-term synaptic plasticity in the amygdala underlies the acquisition of emotional memories, including those learned during Pavlovian fear conditioning. Much less is known about the synaptic mechanisms involved in other forms of associative learning, including extinction, that up...

journal_title：Brain research

authors： Maren S

更新日期：2015-09-24 00:00:00

abstract：:Males and females perform differently on a variety of training tasks. In the present study we examined performance of male and female rats while they were trained with a gross motor skill in which they learn to maintain their balance on an accelerating rotating rod (the accelerating rotarod). During training, many ani...

journal_title：Brain research

authors： DiFeo G,Curlik DM 2nd,Shors TJ

更新日期：2015-09-24 00:00:00

abstract：:Spatial learning and memory in rodents represent close equivalents of human episodic declarative memory, which is especially sensitive to cerebral aging, neurodegeneration, and various neuropsychiatric disorders. Many tests and protocols are available for use in laboratory rodents, but Morris water maze and radial-arm...

journal_title：Brain research

authors： Pooters T,Van der Jeugd A,Callaerts-Vegh Z,D'Hooge R

更新日期：2015-09-24 00:00:00

abstract：:Generation and persistence of tinnitus following hearing loss may be due to aberrant engagement of attention. Here, functional MRI was used to determine differences in auditory and visual attention processing in adults with tinnitus and hearing loss compared to two age-matched control groups, one with matched hearing ...

journal_title：Brain research

authors： Husain FT,Akrofi K,Carpenter-Thompson JR,Schmidt SA

更新日期：2015-09-16 00:00:00

abstract：:Mitochondrial division inhibitor (mdivi-1), a selective inhibitor of a mitochondrial fission protein dynamin-related protein 1 (Drp1), has been shown to exert protective effects in heart and cerebral ischemia-reperfusion models. The present study was designed to investigate the beneficial effects of mdivi-1 against sp...

journal_title：Brain research

authors： Liu JM,Yi Z,Liu SZ,Chang JH,Dang XB,Li QY,Zhang YL

更新日期：2015-09-04 00:00:00

abstract：:The injured spinal cord does not heal properly. In contrast, tissue repair and functional recovery occur after skin or muscle injuries. The reason for this dichotomy in wound repair is unclear but inflammation, and specifically macrophage activation, likely plays a key role. Macrophages have the ability to promote the...

journal_title：Brain research

authors： Gensel JC,Zhang B

更新日期：2015-09-04 00:00:00

abstract：:Alzheimer׳s disease (AD) is a neurodegenerative disease with elusive pathogenesis, which accounts for most cases of dementia in the aged population. It has been reported that persistent inflammatory responses and excessive chemotaxis of microglia stimulated by beta-amyloid (Aβ) oligomers in the brain may accelerate th...

journal_title：Brain research

authors： Liu H,Wang J,Wang J,Wang P,Xue Y

更新日期：2015-08-27 00:00:00

abstract：:The aim of this study was to determine the effect of different concentrations of normobaric oxygen (NBO) on neurological function and the expression of caspase-3 and -9 in a rat model of acute cerebral ischaemia. Sprague-Dawley rats (n=120) were randomly divided into four groups (n=30 per group), including 3 groups gi...

journal_title：Brain research

authors： Chen S,Peng H,Rowat A,Gao F,Zhang Z,Wang P,Zhang W,Wang X,Qu L

更新日期：2015-08-27 00:00:00

abstract：:Corticotropin-releasing factor (CRF) in the brain plays an important role in regulations of physiological and behavioral processes, yet CRF distribution in tree shrew brain has not been thoroughly and systematically reported. Here we examined the distribution of CRF immunoreactivity in the brain of tree shrews (Tupaia...

journal_title：Brain research

authors： Shu YM,Ni RJ,Sun YJ,Fang H,Zhou JN

更新日期：2015-08-27 00:00:00

abstract：:There are different kinds of visuomotor learnings. One of the most studied is error-based learning where the information about the sign and magnitude of the error is used to update the motor commands. However, there are other instances where subjects show visuomotor learning even if the use of error sign and magnitude...

journal_title：Brain research

authors： Alfonso Uresti-Cabrera L,Vaca-Palomares I,Diaz R,Beltran-Parrazal L,Fernandez-Ruiz J

更新日期：2015-08-27 00:00:00

abstract：:A newly discovered cell-to-cell communication system involves small, membrane-enveloped nanovesicles, called exosomes. We describe here how these extracellular nanoparticles were discovered and how it became gradually apparent that they play fundamental roles in regulation of physiological functions and pathological p...

journal_title：Brain research

authors： Kawikova I,Askenase PW

更新日期：2015-08-18 00:00:00

abstract：:Tourette syndrome (TS) is a childhood-onset tic disorder associated with abnormal development of brain networks involved in the sensory and motor processing. An involvement of immune mechanisms in its pathophysiology has been proposed. Animal models based on active immunization with bacterial or viral mimics, direct i...

journal_title：Brain research

authors： Martino D,Zis P,Buttiglione M

更新日期：2015-08-18 00:00:00

abstract：:Nuclear factor one X (NFIX) has been shown to play a pivotal role during the development of many regions of the brain, including the neocortex, the hippocampus and the cerebellum. Mechanistically, NFIX has been shown to promote neural stem cell differentiation through the activation of astrocyte-specific genes and via...

journal_title：Brain research

authors： Vidovic D,Harris L,Harvey TJ,Evelyn Heng YH,Smith AG,Osinski J,Hughes J,Thomas P,Gronostajski RM,Bailey TL,Piper M

更新日期：2015-08-07 00:00:00

abstract：STUDY OBJECTIVE:To examine the differential effects of acute and chronic sleep fragmentation (SF) on spatial learning and memory, and hippocampal long-term potentiation (LTP) in pubertal mice. METHODS:Two studies were performed during which adolescent C57/Bl6 mice were subjected to acute-SF 24h a day × 3 days or chron...

journal_title：Brain research

authors： Wallace E,Kim DY,Kim KM,Chen S,Blair Braden B,Williams J,Jasso K,Garcia A,Rho JM,Bimonte-Nelson H,Maganti R

更新日期：2015-07-30 00:00:00

abstract：:Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate wheth...

journal_title：Brain research

authors： Han L,Tian R,Yan H,Pei L,Hou Z,Hao S,Li YV,Tian Q,Liu B,Zhang Q

更新日期：2015-07-30 00:00:00

abstract：:Aging represents a major risk factor for numerous illnesses that are of increasing importance to society, including two of the most prevalent: diabetes and Alzheimer's disease. Studies have shown that diabetes is a risk factor for spontaneous Alzheimer's disease. While these studies suggest that diabetes can contribut...

journal_title：Brain research

authors： Oliveira LT,Leon GVO,Provance DW Jr,de Mello FG,Sorenson MM,Salerno VP

更新日期：2015-07-30 00:00:00

abstract：:The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...

journal_title：Brain research

authors： Shijo K,Ghavim S,Harris NG,Hovda DA,Sutton RL

更新日期：2015-07-21 00:00:00

abstract：UNLABELLED:This study examines the effects of progesterone on blood-brain barrier (BBB) integrity following thrombin administration. Thrombin is expressed in many diseases which affect neural tissue and is associated with breakdown of the BBB. Progesterone has shown protective effects on the BBB in stroke and traumatic...

journal_title：Brain research

authors： Hun Lee J,Won S,Stein DG

更新日期：2015-07-10 00:00:00

abstract：:Lifelong bilingualism is associated with the delayed diagnosis of dementia, suggesting bilingual experience is relevant to brain health in aging. While the effects of bilingualism on cognitive functions across the lifespan are well documented, less is known about the neural substrates underlying differential behaviour...

journal_title：Brain research

authors： Olsen RK,Pangelinan MM,Bogulski C,Chakravarty MM,Luk G,Grady CL,Bialystok E

更新日期：2015-07-01 00:00:00

abstract：:Reward anticipation is associated with activity in the dopaminergic midbrain as well as the ventral striatum, amygdala, and medial prefrontal cortex. Dopaminergic neuromodulation declines with age, suggesting that incentive processing should also undergo age-related change. However, the literature is mixed, perhaps re...

journal_title：Brain research

authors： Spaniol J,Bowen HJ,Wegier P,Grady C

更新日期：2015-07-01 00:00:00

abstract：:In neuronal cultures, glycogen synthase kinase 3(GSK3) is truncated at the N-terminal end by calpain downstream of activated glutamate receptors. However, the in vivo biological significance of that truncation has not been explored. In an attempt to elucidate if GSK3 truncation has a pathophysiological relevance, we h...

journal_title：Brain research

authors： Jurado-Arjona J,Goñi-Oliver P,Rodríguez-Prada L,Engel T,Henshall DC,Ávila J,Hernández F

更新日期：2015-06-22 00:00:00

abstract：:In our previous study, we have found that leucine-rich repeats and immunoglobulin-like domains 1(LRIG1) can improve the chemosensitivity in U251 cells whereas the role of LRIG1 in multidrug resistance (MDR) remains unknown. Here, we reported that LRIG1 can reverse MDR by inhibiting epidermal growth factor (EGF) recept...

journal_title：Brain research

authors： Liu B,Guo Z,Dong H,Daofeng T,Cai Q,Ji B,Zhang S,Wu L,Wang J,Wang L,Zhu X,Liu Y,Chen Q

更新日期：2015-06-22 00:00:00

abstract：:The primate somatosensory neuraxis provides a highly translational model system with which to investigate adult neural plasticity. Here, we report immunohistochemical staining data for AMPA and GABAA/B receptor subunits of area 3b cortex and cuneate nucleus of adult squirrel monkeys one to five years after median and ...

journal_title：Brain research

authors： Mowery TM,Sarin RM,Kostylev PV,Garraghty PE

更新日期：2015-06-22 00:00:00

abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...

journal_title：Brain research

authors： Zhang Y,Shen GL,Shangguan LJ,Yu Y,He ML

更新日期：2015-05-22 00:00:00

abstract：UNLABELLED:Mating in rabbits lasts only 3-5s but profoundly changes the female׳s physiology and behavior (e.g., inhibition of scent-marking and ambulation, changes in EEG, and release of GnRH). The behavioral responsiveness to copulation is reduced in lactating rabbits, relative to estrous does, but is enhanced after s...

journal_title：Brain research

authors： González-Mariscal G,García Dalmán C,Jiménez A

更新日期：2015-05-22 00:00:00

abstract：:The genetic architecture of amyotrophic lateral sclerosis (ALS) is being increasingly understood. In this far-reaching review, we examine what is currently known about ALS genetics and how these genes were initially identified. We also discuss the various types of mutations that might underlie this fatal neurodegenera...

journal_title：Brain research

authors： Marangi G,Traynor BJ

更新日期：2015-05-14 00:00:00

abstract：:Focal adhesion kinase (FAK) and proline-rich tyrosine kinase (PYK2) are two related non-receptor tyrosine kinases which are thought to play a role in transducing extracellular matrix (ECM)-derived survival signals into cells. The functions of FAK and PYK2 are linked to autophosphorylation of their specific tyrosine re...

journal_title：Brain research

authors： Ziemka-Nalecz M,Jaworska J,Sypecka J,Zalewska T

更新日期：2015-05-05 00:00:00